Hands-on Course in Tablet Technology

The University of Mississippi

Advanced Course

Picture of outside of Ashland Laboratory building in Wilmington, Delaware

The Department of Pharmaceutics and Drug Delivery at the University of Mississippi School of Pharmacy is proud to partner with Ashland Specialty Ingredients to offer the Advanced Hands-on Course in Tablet Technology, which takes place at Ashland’s state-of-the-art Research Center in Wilmington, Delaware.

The Advanced Course builds on the fundamental principles taught in the lecture and laboratory sessions of the Hands-on Course in Tablet Technology by providing more in-depth training in selected areas of oral solid dosage form processing and manufacturing for professionals in the pharmaceutical and related industries, including those involved in research and development, manufacturing, quality control/assurance, and regulatory compliance.

Morning lectures provide in-depth background to the science and practice underlying the operations that are then conducted in the laboratory sessions.  

In the 16 hours of hands-on laboratory sessions, participants work in teams to manufacture and evaluate extended-release formulations for granulation, flow properties and segregation potential, tablet compression and compaction simulation, coating performance, continuous manufacturing, hot melt extrusion processing, and conformance to target release rates/IVIVC evaluation.

The Advanced Course is designed for professionals with a fundamental understanding of the science of tablet technology who wish to gain more knowledge and experience in advanced areas of design and practice.

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Sunday Night

6-8:30 p.m. – Registration, Reception and Orientation

Time Monday Tuesday Wednesday Thursday
8 a.m. Powder Characterization – Blending and Flow Properties Extended Release – Tablet Coating Lab Sessions Continuous Processing
9 a.m. Dry Granulation – Roller Compaction Extended Release – Powder and Bead Coating Lab Sessions IVIVC Construction and Considerations
10 a.m. Polymer Science for Pharmaceutical Formulations Melt Extrusion – Solubilization and Extended Release Lab Sessions Presentation and Discussion of Results – Formulation Challenge
and IVIVC Construction
11 a.m. Extended Release – Matrix Systems Compression and Compaction Simulator Studies Lab Sessions
12 p.m Lunch and Formulation Challenge Lunch Lunch
1-5 p.m. Lab Sessions Lab Sessions Lab Sessions


LAB 1 – Powder Characterization

Evaluate properties of prototype and participant-designed formulations for:

  • Flow
  • Compression properties
  • Segregation potential

LAB 2 – Dry Granulation – Roller Compaction

Manufacture extended-release granulations via roller compaction

  • Evaluate effects of equipment parameters on processing
  • Design formula to provide target drug release/plasma profile characteristics

LAB 3 – Compression

Evaluate processing (flow and compressibility) of prototype and participant-designed formulations

  • Effects of formulation components
  • Granulated vs direct compression formulations

LAB 4 – Physical Evaluation and Dissolution

Perform analyses to evaluate tablet characteristics

  • Tablet physical characteristics
  • Tablet hydration and release mechanisms
  • Set up automated dissolution to evaluate drug release over 12 hours

LAB 5 – Hot Melt Extrusion

Evaluate processing of hot melt extruded material

  • Effect of excipients
  • Effect of process/equipment parameters

LAB 6 – Tablet and Bead Coating

Examine extended-release applications of applied coatings using

  • Tablet pan coating equipment
  • Fluid-bed bead coating

LAB 7 – Compaction Simulator Studies

Project processability of prototype and participant-designed formulations on target compression equipment using a compaction simulator

LAB 8 – Continuous Processing

Evaluate manufacture of prototype formulations via a continuous wet granulation process design

Enrollment Contacts

Special Accommodations

Ms. Deborah Herod, Course Coordinator and Registrar

Phone: (662) 915-7341

Fax: (662) 915-1177



Upcoming Courses

Dates coming soon