Hands-on Course in Tablet Technology

The University of Mississippi

Laboratories

LAB 1 – Preformulation

Evaluate properties of a pharmaceutical API, powders and polymers utilizing:

  • Particle surface area analysis
  • Porosity analysis
  • Particle size and shape analysis
  • Density analysis
  • Moisture adsorption/desorption isotherms
  • Texture analysis
  • Thermogravimetric analysis
  • Differential scanning calorimetry

 

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LAB 2 – Granulation and Extrusion/Spheronization

Processing of a pharmaceutical API and excipients to form granules and extrudates by:

  • High shear mixing and wet granulation
  • Low shear mixing and wet granulation
  • Extrusion/Spheronization
  • Fluid bed drying
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LAB 3 – Tableting

Evaluate excipient/drug compressibility and compressibility of wet granulated vs. direct compression tablet formulations utilizing:

  • Instrumented single punch tablet press
  • Instrumented rotary tablet press
  • Equipment to monitor weight, thickness and breaking strength of tablet compacts
  • Software to determine scalability from small to large scale production presses
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LAB 4 – Hot Melt Extrusion, 3D Printing and Tablet Evaluation

Evaluate processing of hot melt extruded forms using:

  • Hot melt extruder
  • 3D Printing

Perform tests to evaluate quality control attributes of tablets using:

  • Tablet dissolution apparatus, real time and interval drug release testing
  • Tablet disintegration testing
  • Tablet friability testing
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LAB 5 – Fluid Bed Granulation/Particle Coating and Tablet Pan Coating

Evaluate granulation of an API/excipient blend and film coating of non-pareil particles using:

  • Fluid bed granulator/Wurster particle coater

Pan coat tablets using:

  • Side vented tablet coating pan
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Upcoming Courses

Due to the ongoing public health concerns surrounding the impact of COVID-19, we regret to announce that the course scheduled for September 13 – 18, 2020, will be postponed until the Spring 2021.  We are sincerely grateful for the time and dedication of our speakers, organizers and lab instructors who make this course successful and look forward to gathering together again for the course offerings in 2021.