Laboratories

LAB 1 – Preformulation

Evaluate properties of a pharmaceutical API, powders and polymers utilizing:

• Particle surface area analysis
• Porosity analysis
• Particle size and shape analysis
• Density analysis
• Moisture adsorption/desorption isotherms
• Texture analysis
• Thermogravimetric analysis
• Differential scanning calorimetry

 

LAB 2 – Granulation and Extrusion/Spheronization

Processing of a pharmaceutical API and excipients to form granules and extrudates by:

• High shear mixing and wet granulation
• Low shear mixing and wet granulation
• Extrusion/Spheronization
• Fluid bed drying

LAB 3 – Tableting

Evaluate excipient/drug compressibility and compressibility of wet granulated vs. direct compression tablet formulations utilizing:

• Instrumented single punch tablet press
• Instrumented rotary tablet press
• Equipment to monitor weight, thickness and breaking strength of tablet compacts
• Software to determine scalability from small to large scale production presses

LAB 4 – Hot Melt Extrusion, 3D Printing and Tablet Evaluation

Evaluate processing of hot melt extruded forms using:

• Hot melt extruder
• 3D Printing

Perform tests to evaluate quality control attributes of tablets using:

• Tablet dissolution apparatus, real time and interval drug release testing
• Tablet disintegration testing
• Tablet friability testing

LAB 5 – Fluid Bed Granulation/Particle Coating and Tablet Pan Coating

Evaluate granulation of an API/excipient blend and film coating of non-pareil particles using:

• Fluid bed granulator/Wurster particle coater

Pan coat tablets using:

• Side vented tablet coating pan

Upcoming Courses

• May 19 – 24, 2024     Hands-on Course in Tablet Technology (Oxford, MS)